When you start Windows NT, NTDETECT searches for the pointing device (usually a mouse). In the course of this process, data is sent to the serial (COM) ports. If a serial mouse is detected, Windows NT disables the port so a device driver for the mouse can load instead. If a device is not detected, Windows NT disables the port. A disabled COM port does not display any information in Control Panel Ports.
Via [support.microsoft.com]